Professor of Epidemiology
Epidemiology and Biostatistics
267.359.6049
ll85@drexel.edu
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Degrees

MD, Preventive Medicine, Shanxi Medical University, Taiyuan, China
MSc, Epidemiology, London School of Hygiene and Tropical Medicine, University of London, UK
PhD, Epidemiology, The University of Hong Kong, Hong Kong, China

Bio

Dr. Longjian Liu is a tenured Full Professor of Epidemiology in the Department of Epidemiology and Biostatistics at the Drexel University Dornsife School of Public Health (SPH) and holds an adjunct professor appointment at the Drexel University College of Medicine. Dr. Liu serves as an advisor to PhD and MPH students. He has also served on numerous departmental, school, and university committees. His leadership roles include serving as the former Interim Chair of the Department of Environmental and Occupational Health and former Chair of the School’s MPH Admissions Committee.

As an NIH-funded Principal Investigator, Dr. Liu’s research leverages large-scale longitudinal epidemiological studies in the United States, including MESA, WHI, ARIC, HRS, and the Health ABC Study, as well as major national health surveys (NHANES, NHDS, NHIS, BRFSS, NIS, MEPS, and LSOAs). His work also spans international health initiatives with Japan and the World Health Organization, including NIPPON DATA, the WHO-CARDIAC Study, and the WHO-WHS. Dr. Liu has authored over 120 peer-reviewed journal articles, textbooks, and book chapters.

Courses

EPI 749: Research and Practice in Epidemiology

EPI 557: Cardiovascular Disease Epidemiology and Prevention

EPI 559: Pharmacoepidemiology

Research Interests

• Nutrition, Cardio-Kidney-Metabolic (CKM) health, and cardiovascular outcomes
• The interplay of nutrition, CKM, genetics, and social determinants on the risk of cardiovascular and brain aging/dementia
• Application of Artificial Intelligence and Machine Learning (AI/ML) techniques to enhance outcomes research and risk prediction modeling
• Advanced analysis of longitudinal survey data, medical claims, and Electronic Health Records (EHRs)
• Global Health

Publications

Selected publications

Longjian Liu and Jintong Hou: Machine learning-based LASSO-Cox model for dementia prediction: The role of midlife cardiometabolic, inflammatory, and genetic risk factors in a US cohort. Annals of Epidemiology, 2026;115:28-36. PMID: 41581843.

Longjian Liu, Jintong Hou, Saishi Cui, Xiaopeng Zhao, Zuolu Liu, J. Craig Longenecker, Nathalie S. May, Jin Jun Luo, Rose Ann DiMaria-Ghalili, and Howard J. Eisen: Sex Differences in the Association of Vascular Risk and APOE Genotype on Cognitive Decline and Dementia: Evidence from a U.S. Longitudinal Study. The Lancet Regional Health – Americas, 2026;54:101346. PMID: 41536502, PMCID12796570.

Jacques E. Rossouw, Aaron K. Aragaki, JoAnn E. Manson, Emily D. Szmuilowicz, Laura B. Harrington, Karen C. Johnson, Matthew Allison, Bernhard Haring, Nazmus Saquib, Aladdin H. Shadyab, Kathryn M. Rexrode, Longjian Liu, Charles P. Mouton, and Andrea Z. LaCroix: Menopausal Hormone Therapy and Cardiovascular Diseases in Women With Vasomotor Symptoms: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trials. JAMA Intern Medicine, Sept 2025, PMID: 40952729.

Longjian Liu, Edward J Gracely, Xiaopeng Zhao, Gediminas P Gliebus, Nathalie S. May, Stella L. Volpe, Jingyi Shi, Rose Ann DiMaria-Ghalili, and Howard J Eisen: Association of Multiple Metabolic and Cardiovascular Markers with Risk of Cognitive Decline and Mortality in Those with Alzheimer’s Disease and AD-related Dementia: A Prospective Cohort Study. Frontiers in Aging Neuroscience, 2024;2:16, PMCID: PMC11020085.

Alexander Alsup, Emily Nissen, Lucas A. Salas, Annette M. Molinaro, Alexander Reiner, Simin Liu, Tracey Madsen, Longjian Liu, Brock C. Christensen, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler: An Assessment of Compositional Methods for the Analysis of DNA Methylation-based Deconvolution Estimates. Epigenomics (Taylor & Francis, UK), publication online first on Aug02, 2024. PMID: 39093129.

Longjian Liu, Julianne Nelson, Craig J. Newschaffer, and Patrick L. Remington, Ross C. Brownson, and Mark V. Wegner: Chapter 16: Cardiovascular Disease in APHA coordinated textbook: Chronic Disease Epidemiology, Prevention, and Control, 5th edition, American Public Health Association (APHA) Press, Oct 2023.

Longjian Liu, Kathleen M. Hayden, Nathalie S. May, Bernhard Haring, Zuolu Liu, Victor W. Henderson, Jiu-Chiuan Chen, Edward J Gracely, Sylvia Wassertheil-Smoller, and Stephen R. Rapp: Association Between Blood Pressure Levels and Cognitive Impairment in Older Women: A Prospective Analysis of The Women’s Health Initiative Memory Study. The Lancet Healthy Longevity, Jan 2022, PMCID: PMC8804967.

Longjian Liu, Stella L. Volpe, Jennifer A Ross, Elisabeth J Van Bockstaele, and Howard J Eisen: Dietary Sugar Intake and Risk of Alzheimer’s Disease in Older Women. 2021 June, Nutritional Neuroscience. PubMed PMID 34328409.

Longjian Liu, Joao Lima, Wendy S Post, and Moyses Szklo: Association of obesity and metabolic syndrome with risk of heart failure and its subtypes in the Multi-Ethnic Study of Atherosclerosis. International Journal of Cardiology, June 2021, PubMed PMID: 34089770.

Longjian Liu, Liviu Klein; Charles Eaton; Gurusher Panjrath; Lisa Warsinger Martin; Claudia U. Chae; Philip Greenland; Donald M Lloyd-Jones; Jean Wactawski-Wende; and JoAnn E. Manson: Menopausal Hormone Therapy and Risks of First Hospitalized Heart Failure and Its Subtypes During the Intervention and Extended Postintervention Follow-up of the Women’s Health Initiative Randomized Trials. Journal Cardiac Failure, 2020 26(1)2-12. PubMed PMID: 3156806.

See Dr. Lui's full list of key publications on PubMed